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Falk Nimmerjahn1,2 and Anne Barenwaldt2 1Institute of Genetics, Department of Biology, University of Erlangen-Niirnberg, Erlangen, Germany 2Department of Biomedicine, University of Basel, Basel, Switzerland Synonyms CD32B; Fc fragment of IgG low-affinity IIb receptor Definition FcyRIIB is a low-affinity receptor Ka = 107 M_1 for the constant region of immunoglobulin G IgG and belongs to the family of Fcg-receptors FcgR.

Resolution of Inflammation
Ann C. Skulas-Ray Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA Synonyms Catabasis; Lipid-mediator class switching Definition Resolution of inflammation is the termination of an inflammatory response.

Sarika Ramachandran The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA Synonyms Psoriasis vulgaris Definition Psoriasis is an inflammatory, immune-mediated disease which can involve the skin, nails, and joints.

Leonard H. Sigal Departments of Medicine and Pediatrics, Department of Molecular Genetics and Microbiology, UMDNJ - Robert Wood Johnson Medical School, New Brunswick, NJ, USA Synonyms B reg - B regulatory cell; B10 - B cell producing IL-10; BAFF/BLyS - B cell activating factor/B lymphocyte stimulator BCR - B cell antigen receptor; CaMKII - Ca +/calmodulin-dependent kinase; CLL - chronic lymphocytic leukemia; DC - dendritic cell; EAE - autoimmune experimental acute encephalomyelitis; gp - glycoprotein; ITAM – Immunoreceptor Tyrosine-based Activation Motif; ITIM - Immunoreceptor Tyrosine-based Inhibitory Motif; MARCO - macrophage receptor with col­lagenous structure; MOG - myelin oligodendro­cyte glycoprotein; PAMP - pathogen-associated molecular patterns; PC-PLC - Phosphatidylcho-line-specific Phospholipase C; PI3K - Phosphati-dylinositol 3-kinase; PRR - pathogen recognition receptor; PTP1C - Phosphotyrosine Phosphatase 1C; RAS-GAP-Ras GTPase activating protein; SHP-1 - Src homology region 2 domain-containing phosphatase-1; SLE - systemic lupus erythematosus; SRCR - scavenger receptor cysteine rich; T reg - regulatory T cell; TCR - T cell antigen receptor; TdT - terminal deoxynucleotidyl transferase Definition CD5 previous names for CD5 have included Leu-1, Ly-1, OKT-1, T1, and Tp67 is a surface glycoprotein found in association with both the T cell antigen receptor TCR and the B cell Antigen receptor BCR.

Klaus Okkenhaug Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK Synonyms Phosphatidylinositol 3-kinase; Phosphoinositide 3-kinase; PI 3-kinase Definition PI3Ks are a family of enzymes that can phosphor-ylate the inositol head group of phosphoinositides PtdIns on the D3 position.

Antiphospholipid Syndrome, Clinical Manifestations
Yaniv Sherer Hospital Management, Tel-Aviv Sourasky Medical Center and Sackler, Tel-Aviv University, Tel-Aviv, Israel Synonyms APS - clinical manifestations Definition Antiphospholipid syndrome is a systemic autoimmune disease characterized by various clinical manifestations the most characteristic are thromboses and pregnancy morbidity in the presence of elevated levels of antiphospholipid antibodies.

Systemic Autoimmune Disease and Premature Atherosclerosis
Jason S. Knight1 and Mariana J. Kaplan2 1Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA 2Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA Synonyms Cardiovascular disease CVD = atherosclerotic disease; Premature atherosclerosis = accelerated latherosclerosis; Systemic autoimmune disease = rheumatologic disease Definition Premature atherosclerosis is the formation of arterial atheromatous plaques at an earlier age than would be expected based on traditional Framingham CV risk factors.

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